Concepedia

Ficus hirta Vahl. ameliorates liver fibrosis by triggering hepatic stellate cell ferroptosis through GSH/GPX4 pathway

Yuxuan Yang, Dongge Feng, Huixing Wu, Changrui Long, Jianping Zhang, Jinghao Wang, Benjie Zhou, Shasha Li, Shijian Xiang

Journal of Ethnopharmacology · 2024 · 13 citations · 16 references

DOIFull text

Open access

Abstract

Ficus hirta Vahl triggered the ferroptosis of hepatic stellate cell by regulating the GSH/GPX4 pathway, thereby alleviating liver fibrosis in mice. Moreover, apigenin is a key compound in Ficus hirta Vahl responsible for the effective treatment of liver fibrosis.

References

16

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell · 2012 · 17K citations · Full text

, , +9

The global, regional, and national burden of cirrhosis by cause in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Sadaf G Sepanlou, Saeid Safiri, Catherine Bisignano et al. · ˜The œLancet. Gastroenterology & hepatology · 2020 · 1.6K citations · Full text

Liver cirrhosis

The Lancet · 2021 · 1.4K citations

Hepatic transferrin plays a role in systemic iron homeostasis and liver ferroptosis

Yingying Yu, Li Jiang, Hao Wang et al. · Blood · 2020 · 567 citations · Full text

Aberrant iron distribution via hepatocyte-stellate cell axis drives liver lipogenesis and fibrosis

Hong Gao, Zhongmou Jin, Gautam Bandyopadhyay et al. · Cell Metabolism · 2022 · 192 citations · Full text

, , +18