Concepedia

Aryl hydrocarbon receptor confers protection against macrophage pyroptosis and intestinal inflammation through regulating polyamine biosynthesis

Yajing Gao, Kwei-Yan Liu, Wenfeng Xiao, Xueru Xie, Qiuyan Liang, Zikun Tu, Lan Yang, Hongmiao Yu, Haiyan Guo, Saihua Huang,

Theranostics · 2024 · 38 citations · 50 references

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Concepts

Abstract

These findings suggest a functional role for the AhR/ODC1/polyamine axis in maintaining intestinal homeostasis, providing potential targets for treatment of inflammatory bowel disease.

References

50

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations

, , +14

A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids

D. Wessel, U.I. Flügge · Analytical Biochemistry · 1984 · 4.1K citations

, , +12

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

Francisco J. Quintana, Alexandre S. Basso, Antonio Iglesias et al. · Nature · 2008 · 1.8K citations

, , +14

Intestinal microbiota-derived short-chain fatty acids regulation of immune cell IL-22 production and gut immunity

Wenjing Yang, Tianming Yu, Xiangsheng Huang et al. · Nature Communications · 2020 · 1K citations · Full text

, , +17

The NLRP3 Inflammasome Protects against Loss of Epithelial Integrity and Mortality during Experimental Colitis

Hasan Zaki, Kelli L. Boyd, Peter Vogel et al. · Immunity · 2010 · 976 citations · Full text

, , +16