Concepedia

Chlorogenic acid can improve spermatogenic dysfunction in rats with varicocele by regulating mitochondrial homeostasis and inhibiting the activation of NLRP3 inflammasomes by oxidative mitochondrial DNA and cGAS/STING pathway

Zhichao Jia, Shengjing Liu, Tengfei Chen, Zhuozhuo Shi, Xiaolin Li, Zhaowang Gao, Qian Zhang, Chongfu Zhong

Bioorganic Chemistry · 2024 · 17 citations · 41 references

DOI

Concepts

References

41

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Hongxu Xian, Kosuke Watari, Elsa Sánchez‐López et al. · Immunity · 2022 · 755 citations · Full text

, , +16

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Moritz M. Gaidt, Thomas S. Ebert, Dhruv Chauhan et al. · Cell · 2017 · 637 citations · Full text

, , +15

Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Weifeng Zhang, Gaocai Li, Rongjin Luo et al. · Experimental & Molecular Medicine · 2022 · 323 citations · Full text

, , +15

Cytosolic DNA‐STING‐NLRP3 axis is involved in murine acute lung injury induced by lipopolysaccharide

Ning Li, Wei Wang, Rui Xiong et al. · Clinical and Translational Medicine · 2020 · 275 citations · Full text

, , +14

Sperm nuclear DNA fragmentation and mitochondrial activity in men with varicocele

Camile Garcia Blumer, R.M. Fariello, A.E. Restelli et al. · Fertility and Sterility · 2008 · 165 citations · Full text

, , +13