Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis

Weifeng Zhang, Gaocai Li, Rongjin Luo, +14

Experimental & Molecular Medicine

WTAP-mediated m6A modification of lncRNA NORAD promotes intervertebral disc degeneration

Gaocai Li, Liang Ma, Shujie He, +12

Nature Communications

Exosomal transfer of miR-15b-3p enhances tumorigenesis and malignant transformation through the DYNLT1/Caspase-3/Caspase-9 signaling pathway in gastric cancer

Shuchun Wei, Lei Peng, Jiajia Yang, +7

Journal of Experimental & Clinical Cancer Research

Oligodendrocyte-derived extracellular vesicles as antigen-specific therapy for autoimmune neuroinflammation in mice

Giacomo Casella, Javad Rasouli, Alexandra Boehm, +12

Science Translational Medicine

m6A hypomethylation of DNMT3B regulated by ALKBH5 promotes intervertebral disc degeneration via E4F1 deficiency

Gaocai Li, Rongjin Luo, Weifeng Zhang, +12

Clinical and Translational Medicine

Ligand recognition and G-protein coupling of trace amine receptor TAAR1

Zheng Xu, Lulu Guo, Jingjing Yu, +27

Nature

Signal TransductionBiochemistryG Protein-coupled ReceptorNatural SciencesFunctional Selectivity +6

The NLRX1-SLC39A7 complex orchestrates mitochondrial dynamics and mitophagy to rejuvenate intervertebral disc by modulating mitochondrial Zn ²⁺ trafficking

Yu Song, Huaizhen Liang, Gaocai Li, +11

Autophagy

A distinct GM-CSF ⁺ T helper cell subset requires T-bet to adopt a T _H 1 phenotype and promote neuroinflammation

Javad Rasouli, Giacomo Casella, Satoshi Yoshimura, +13

Science Immunology

Differential expression of miR‐195 in esophageal squamous cell carcinoma and miR‐195 expression inhibits tumor cell proliferation and invasion by targeting of Cdc42

Mingen Fu, Shuo Li, Tingting Yu, +11

FEBS Letters

Nanotopography Sequentially Mediates Human Mesenchymal Stem Cell-Derived Small Extracellular Vesicles for Enhancing Osteogenesis

Liang Ma, Gaocai Li, Jie Lei, +11

ACS Nano

Tissue EngineeringEngineeringEnhancing OsteogenesisBone RepairExtracellular Microvesicles +19