Ag nanoisland functionalized hollow carbon nanofibers as a non-invasive, label-free SERS salivary biosensor platform for salivary nitrite detection for pre-diagnosis of oral cancer

Abstract

M with R6G, demonstrating its efficacy to investigate real-time salivary samples, particularly towards the detection of salivary nitrite within the clinically relevant range (50 μM-300 μM) towards the pre-diagnosis of oral cancer. The proposed SERS-based salivary platform has the potential to be used as a low-cost, non-invasive pre-diagnostic tool for early diagnosis and mass screening of oral cancer.