iScience · 2024 · 22 citations · 56 references
MedicineImmunologyOncologyCancer ImmunologyTumor ImmunologyTumor MicroenvironmentCancer BiomarkersCancer ImmunotherapyImmuno-oncology BiomarkersSignal Transduction In CancerTumor Microenvironment ModulationTumor-associated MacrophagesAntigen Presentation SignalingMacrophage PolarizationMacrophage Polarization BiomarkersSingle-cell Rna SequencingTriple-negative Breast Cancer RecurrenceTriple-negative Breast Cancer TherapyTumor Microenvironment BiomarkersTumor-associated Macrophage Polarization
-high macrophages, providing potential therapeutic targets for new strategies. In conclusion, YTHDF2 in macrophages appears to promote pro-tumoral effects while suppressing immune activity, indicating the treatment targeting YTHDF2 or its transcription factors could be a promising strategy for chemoresistant TNBC.
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