Unveiling the promising anticancer activity of palladium(<scp>ii</scp>)–aryl complexes bearing diphosphine ligands: a structure–activity relationship analysis

Abstract

Pd–aryl complexes bearing a wide range of disphosphine, aryl and halide ligands were synthesized. Their remarkable in vitro and ex vivo anticancer activity seems to involve DNA as the main biotarget and an intrinsic apoptotic cell death mechanism.