EGFR Oncogenic Mutations in NSCLC Impair Macrophage Phagocytosis and Mediate Innate Immune Evasion Through Up-Regulation of CD47

Mutational landscape determines sensitivity to PD-1 blockade in non–small cell lung cancer

Naiyer A. Rizvi, Matthew D. Hellmann, Alexandra Snyder et al. · Science · 2015 · 7.9K citations

Medicine, Immunology, Oncology +17

MYC regulates the antitumor immune response through CD47 and PD-L1

Stephanie C. Casey, Ling Tong, Yulin Li et al. · Science · 2016 · 1.4K citations · Full text

Medicine, Cancer Biology, Oncology +17

Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors

Esra A. Akbay, Shohei Koyama, Julián Carretero et al. · Cancer Discovery · 2013 · 1.2K citations · Full text

Medicine, Immunology, Oncology +17

Upregulation of PD-L1 by EGFR Activation Mediates the Immune Escape in EGFR-Driven NSCLC: Implication for Optional Immune Targeted Therapy for NSCLC Patients with EGFR Mutation

Nan Chen, Wenfeng Fang, Jianhua Zhan et al. · Journal of Thoracic Oncology · 2015 · 686 citations · Full text

Medicine, Immunology, Oncology +17

Genomic landscape of lung adenocarcinoma in East Asians

Jianbin Chen, Hechuan Yang, Audrey Su Min Teo et al. · Nature Genetics · 2020 · 544 citations

Medicine, Genetics, Oncology +12