Targeting ESE3/EHF With Nifurtimox Inhibits CXCR2+ Neutrophil Infiltration and Overcomes Pancreatic Cancer Resistance to Chemotherapy and Immunotherapy

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

Daniel D. Von Hoff, Thomas J. Ervin, Francis P. Arena et al. · New England Journal of Medicine · 2013 · 6.7K citations

Medicine, Oncology, Pharmacology +13

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

Kyle J. Eash, Adam Greenbaum, Priya Gopalan et al. · Journal of Clinical Investigation · 2010 · 777 citations · Full text

Life Sciences, Cell Biology, Immunology +16

Targeting both tumour-associated CXCR2⁺ neutrophils and CCR2⁺ macrophages disrupts myeloid recruitment and improves chemotherapeutic responses in pancreatic ductal adenocarcinoma

Timothy M. Nywening, Brian A. Belt, Darren R. Cullinan et al. · Gut · 2017 · 481 citations · Full text

Medicine, Immunology, Oncology +17

Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer

Yu Zhang, Vidhi Chandra, Erick Riquelme et al. · The Journal of Experimental Medicine · 2020 · 451 citations · Full text

Medicine, Immunology, Oncology +17

Regulatory T-cell and neutrophil extracellular trap interaction contributes to carcinogenesis in non-alcoholic steatohepatitis

Han Wang, Hongji Zhang, Yu Wang et al. · Journal of Hepatology · 2021 · 380 citations · Full text

Medicine, Immunology, Pathology +16