Association of β-Amyloid, Microglial Activation, Cortical Thickness, and Metabolism in Older Adults Without Dementia

Abstract

These findings suggest that plasma Aβ₄₂/Aβ₄₀ abnormalities may predate CSF Aβ₄₂/Aβ₄₀ and Aβ-PET abnormalities. Higher sTREM2-related microglial activation is linked to thicker cortical thickness and higher metabolism in early amyloidosis stages but tends to mitigate Aβ accumulation primarily at relatively advanced stages.