Concepedia

mtDNA-cGAS-STING axis-dependent NLRP3 inflammasome activation contributes to postoperative cognitive dysfunction induced by sevoflurane in mice

Nan‐Shi‐Yu Yang, Wenjing Zhong, Han-Xi Sha, Chen‐Yu Zhang, Ling Jin, Jia‐Xi Duan, Jian‐Bing Xiong, Zhi-Jian You, Yong Zhou, Cha‐Xiang Guan

International Journal of Biological Sciences · 2024 · 110 citations · 56 references

DOIFull text

Open access

Concepts

Abstract

the mPTP-VDAC channel inhibitor attenuated sevoflurane-induced mtDNA cytosolic escape and reduced cGAS-STING pathway activation in microglia, finally inhibiting the NLRP3 inflammasome activation. Therefore, regulating neuroinflammation by targeting the cGAS-STING pathway may provide a novel therapeutic target for POCD.

References

56

cGAS–STING drives ageing-related inflammation and neurodegeneration

Muhammet F. Gülen, Natasha Samson, Alexander Keller et al. · Nature · 2023 · 925 citations · Full text

, , +17

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Hongxu Xian, Kosuke Watari, Elsa Sánchez‐López et al. · Immunity · 2022 · 755 citations · Full text

, , +16

The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3

Moritz M. Gaidt, Thomas S. Ebert, Dhruv Chauhan et al. · Cell · 2017 · 637 citations · Full text

, , +15

ADVERSE CEREBRAL EFFECTS OF ANÆSTHESIA ON OLD PEOPLE

P.D. Bedford · The Lancet · 1955 · 477 citations

, , +4

Inhibition of double‐strand DNA‐sensing cGAS ameliorates brain injury after ischemic stroke

Qian Li, Yuze Cao, Chun Dang et al. · EMBO Molecular Medicine · 2020 · 289 citations · Full text

, , +15