Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing

Abstract

Collectively, our results reveal the effect of CGRP on M1 to M2 macrophage phenotypic alteration possibly via upregulating IL-6 in M1 macrophages, and demonstrate the macrophage-regulated pro-angiogenic potential of CGRP in early bone healing.