Smart responsive Fe/Mn nanovaccine triggers liver cancer immunotherapy via pyroptosis and pyroptosis-boosted cGAS-STING activation

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3K citations

Medicine, Apoptosis, Pyroptosis +9

Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy

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Amplifying STING activation by cyclic dinucleotide–manganese particles for local and systemic cancer metalloimmunotherapy

Xiaoqi Sun, Yu Zhang, Jiaqian Li et al. · Nature Nanotechnology · 2021 · 694 citations · Full text

Sting Activation, Bioactive Metal, Cyclic Dinucleotide–manganese Particles +7

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis 

Bo Zhou, Jia-yuan Zhang, Xian-shuo Liu et al. · Cell Research · 2018 · 638 citations · Full text

Checkpoint blockade and nanosonosensitizer-augmented noninvasive sonodynamic therapy combination reduces tumour growth and metastases in mice

Wenwen Yue, Liang Chen, Luodan Yu et al. · Nature Communications · 2019 · 578 citations · Full text