Exploring antibiotic resistance mechanisms in Mycobacterium abscessus for enhanced therapeutic approaches

Abstract

<i>Mycobacterium abscessus</i>, a leading cause of severe lung infections in immunocompromised individuals, poses significant challenges for current therapeutic strategies due to resistance mechanisms. Therefore, understanding the intrinsic and acquired antibiotic resistance of <i>M. abscessus</i> is crucial for effective treatment. This review highlights the mechanisms employed by <i>M. abscessus</i> to sustain antibiotic resistance, encompassing not only conventional drugs but also newly discovered drug candidates. This comprehensive analysis aims to identify novel entities capable of overcoming the notorious resistance exhibited by <i>M. abscessus</i>, providing insights for the development of more effective therapeutic interventions.