Novel inhibitors targeting the PGK1 metabolic enzyme in glycolysis exhibit effective antitumor activity against kidney renal clear cell carcinoma in vitro and in vivo

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians · 2021 · 112.5K citations · Full text

Medicine, Oncology, Cancer Epidemiology +16

Hallmarks of Cancer: New Dimensions

Cancer Discovery · 2022 · 9.1K citations · Full text

Medicine, Cancer Biology, Oncology +17

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

Zhenming Jin, Xiaoyu Du, Yechun Xu et al. · Nature · 2020 · 4.5K citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +10

Target identification using drug affinity responsive target stability (DARTS)

Brett Lomenick, Rui Hao, Nao Jonai et al. · Proceedings of the National Academy of Sciences · 2009 · 1.1K citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +13

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

David Clark, Saravana M. Dhanasekaran, Francesca Petralia et al. · Cell · 2019 · 774 citations · Full text

Medicine, Oncology, Pathobiology +17