Journal of the National Comprehensive Cancer Network · 2024 · 48 citations · 41 references
MedicineOncologySurgeryNeoplasiaOncologic SurgerySurgical OncologyCancer DiagnosisCancer StagingLocalized Disease ManagementMalignant NeoplasmsMerkel Cell CarcinomaTumor ClassificationExpert Panel ReviewExpert ReviewExpert Review PanelsMerkel Cell Carcinoma HistopathologyMerkel Cell Carcinoma StagingMerkel Cell Carcinoma TherapyStaging Of Advanced DiseaseTnm Staging System
The NCCN Guidelines for Merkel Cell Carcinoma (MCC) provide recommendations for diagnostic workup, clinical stage, and treatment options for patients. The panel meets annually to discuss updates to the guidelines based on comments from expert review from panel members, institutional review, as well as submissions from within NCCN and external organizations. These NCCN Guidelines Insights focus on the introduction of a new page for locally advanced disease in the setting of clinical node negative status, entitled "Clinical N0 Disease, Locally Advanced MCC." This new algorithm page addresses locally advanced disease, and the panel clarifies the meaning behind the term "nonsurgical" by further defining locally advanced disease. In addition, the guideline includes the management of in-transit disease and updates to the systemic therapy options.
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PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma
Paul Nghiem, Shailender Bhatia, Evan J. Lipson et al. · New England Journal of Medicine · 2016 · 1.2K citations · Full text
Medicine, Dermatology, Oncology +17