Concepedia

Targeting Ferroptosis-Elicited Inflammation Suppresses Hepatocellular Carcinoma Metastasis and Enhances Sorafenib Efficacy

Ming Mu, Chun-Xiang Huang, Chuang Qu, Pei-Lin Li, Xiang-Ning Wu, Wudexin Yao, Chu Shen, R Huang, Chao-Chao Wan, Zhi‐Wei Jian,

Cancer Research · 2024 · 39 citations · 28 references

DOIFull text

Open access

Abstract

Ferroptosis induces a favorable tumor microenvironment and supports liver cancer progression by stimulating an inflammatory cellular network that can be targeted to suppress metastasis and improve the efficacy of sorafenib.

References

28

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell · 2012 · 17K citations · Full text

, , +9

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

Ann‐Lii Cheng, Yoon‐Koo Kang, Zhendong Chen et al. · The Lancet Oncology · 2008 · 5.8K citations

, , +12

Determining cell type abundance and expression from bulk tissues with digital cytometry

Aaron M. Newman, Chloé B. Steen, Chih Long Liu et al. · Nature Biotechnology · 2019 · 4.6K citations

, , +10

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

, , +12

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

Weimin Wang, Michael D. Green, Jae Eun Choi et al. · Nature · 2019 · 2.7K citations · Full text

, , +7