Concepedia

Knockdown of NEAT1 prevents post-stroke lipid droplet agglomeration in microglia by regulating autophagy

Yongli Pan, Wenqiang Xin, Wei Wei, Lars Tatenhorst, Irina Graf, Aurel Popa‐Wagner, Stefan T. Gerner, Sabine Huber, Dirk M. Hermann, Mathias Bähr,

Cellular and Molecular Life Sciences · 2024 · 20 citations · 35 references

DOIFull text

Open access

Abstract

NEAT1 is a key player of LD agglomeration and autophagy stimulation, and NEAT1 knockdown provides a promising therapeutic value against stroke.

References

35

Autophagy regulates lipid metabolism

Rajat Singh, Susmita Kaushik, Yongjun Wang et al. · Nature · 2009 · 3.8K citations · Full text

, , +7

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

Julia Marschallinger, Tal Iram, Macy E. Zardeneta et al. · Nature Neuroscience · 2020 · 1.3K citations · Full text

, , +12

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

Bradlee L. Heckmann, Brett J.W. Teubner, Bart Tummers et al. · Cell · 2019 · 480 citations · Full text

, , +15

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

Oliver Florey, Sung Eun Kim, Cynthia P. Sandoval et al. · Nature Cell Biology · 2011 · 447 citations

, , +15

Long non-coding RNA NEAT1-modulated abnormal lipolysis via ATGL drives hepatocellular carcinoma proliferation

Xirui Liu, Yingjian Liang, Ruipeng Song et al. · Molecular Cancer · 2018 · 261 citations · Full text