Heterogeneity‐induced <scp>NGF‐NGFR</scp> communication inefficiency promotes mitotic spindle disorganization in exhausted T cells through <scp>PREX1</scp> suppression to impair the anti‐tumor immunotherapy with <scp>PD</scp>‐1 <scp>mAb</scp> in hepatocellular carcinoma

Abstract

Inefficiency in NGF-NGFR communication impairs PD-1 mAb immunotherapy and could thus be utilized as a novel therapeutic target in the treatment of HCC patients in clinical practice.