THE COMBINATION OF ORGANIC ANIONS WITH SERUM ALBUMIN

Abstract

Recent investigations have shown that sodium caprylate and related compounds have great influence upon thermal stability (l-3), electrophoretic mobility (4), rate of papain digestion (5), and urea denaturation (6-8) of bovine and human serum albumin.The combination of certain organic anions with native bovine albumin has recently been investigated by the equilibrium dialysis technique by Klotz et al. ( 9) and Teresi and Luck.1The present investigation is an extension of the work of Boyer et al. ( 7) on urea denat'uration.A number of compounds of related structure have been examined for ability to prevent the viscosity rise which occurs when a mixture of albumin and 6 M urea is allowed to stand at room temperature EXPERIMENTAL