Exploration of costunolide derivatives as potential anti-inflammatory agents for topical treatment of atopic dermatitis by inhibiting MAPK/NF-κB pathways

Costunolide covalently targets NACHT domain of NLRP3 to inhibit inflammasome activation and alleviate NLRP3-driven inflammatory diseases

Haowen Xu, Jiahao Chen, Pan Chen et al. · Acta Pharmaceutica Sinica B · 2022 · 88 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Synthesis of 13-amino costunolide derivatives as anticancer agents

Sanjay K. Srivastava, Aji Abraham, Beena Bhat et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 48 citations

Medicine, Medicinal Chemistry, Oncology +10

Costunolide, a sesquiterpene lactone, inhibits the differentiation of pro-inflammatory CD4 + T cells through the modulation of mitogen-activated protein kinases

Eunchong Park, Ju Han Song, Myun Soo Kim et al. · International Immunopharmacology · 2016 · 39 citations

Life Sciences, Immunology, Pharmacology +14

Inhibitory effects of sesquiterpenes from<i>Saussurea lappa</i>on the overproduction of nitric oxide and TNF-α release in LPS-activated macrophages

Feng Zhao, Hui Xu, En-Qi He et al. · Journal of Asian Natural Products Research · 2008 · 38 citations

Medicine, Medicinal Chemistry, Pharmacology +15

Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors

Yanling Tang, Xi Zheng, Qi Yan et al. · Bioorganic Chemistry · 2020 · 37 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12