Concepedia

Highly potent and selective phosphatidylinositol 4-kinase IIIβ inhibitors as broad-spectrum anti-rhinoviral agents

Avinash G. Vishakantegowda, Dasom Hwang, Prashant Chakrasali, Eunhye Jung, Joo‐Youn Lee, Jin Soo Shin, Young‐Sik Jung

RSC Medicinal Chemistry · 2023 · 10 citations · 18 references

DOIFull text

Open access

Concepts

Abstract

value of 0.016 μM for PI4KIIIβ, but not for PI4KIIIα (>10 μM). Therefore, 7f represents a highly potent and selective PI4KIIIβ inhibitor for the further development of antiviral therapy against hRVs or other enteroviruses.

References

18

Palladium(0)-Catalyzed Cross-Coupling Reaction of Alkoxydiboron with Haloarenes: A Direct Procedure for Arylboronic Esters

Tatsuo Ishiyama, Miki Murata, Norio Miyaura · The Journal of Organic Chemistry · 1995 · 1.6K citations

, , +14

A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Zachary A. Knight, Beatriz González, Morri E. Feldman et al. · Cell · 2006 · 1.2K citations · Full text

, , +14

Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production

Simon Message, Vasile Laza‐Stanca, Patrick Mallia et al. · Proceedings of the National Academy of Sciences · 2008 · 488 citations · Full text

, , +15

In Vitro Antiviral Activity of AG7088, a Potent Inhibitor of Human Rhinovirus 3C Protease

Amy K. Patick, Susan L. Binford, M. A. Brothers et al. · Antimicrobial Agents and Chemotherapy · 1999 · 224 citations · Full text

, , +16

Rhinoviruses replicate effectively at lower airway temperatures

Nikolaos G. Papadopoulos, Gwendolyn Sanderson, Sebastian L. Johnston · Journal of Medical Virology · 1999 · 211 citations

, , +14