The SH-SY5Y cell line: a valuable tool for Parkinson’s disease drug discovery

Abstract

Encouraged by recent research on SH-SY5Y cell lines, it was envisaged that this <i>in vitro</i> model can serve as a primary model for assessing efficacy and toxicity of new therapeutics as well as for nanocarriers' capacity in delivering therapeutic agents across BBB. Considering the proximity with human neuronal environment as in pathogenic PD conditions, SH-SY5Y cell lines vindicated consistency and reproducibility in experimental results. Accordingly, exploitation of this standardized SH-SY5Y cell line can fast-track the drug discovery and development path for novel therapeutics.