Genetic insights into associations of multisite chronic pain with common diseases and biomarkers using data from the UK Biobank

Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Theo Vos, Stephen S Lim, Cristiana Abbafati et al. · The Lancet · 2020 · 19.2K citations · Full text

Public Health, Health Sciences, Epidemiologic Methods +16

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden, George Davey Smith, Stephen Burgess · International Journal of Epidemiology · 2015 · 10.6K citations · Full text

Public Health, Biostatistics, Genetics +15

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden, George Davey Smith, Philip Haycock et al. · Genetic Epidemiology · 2016 · 9.6K citations · Full text

Life Sciences, Biostatistics, Genetics +12

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Marie Verbanck, Chia‐Yen Chen, Benjamin M. Neale et al. · Nature Genetics · 2018 · 9.2K citations

Public Health, Biostatistics, Genetics +12

The MR-Base platform supports systematic causal inference across the human phenome

Gibran Hemani, Jie Zheng, Benjamin Elsworth et al. · eLife · 2018 · 8.4K citations · Full text

Life Sciences, Biostatistics, Genetics +16