Concepedia

Vascular endothelial growth factor induces the migration of human airway smooth muscle cells by activating the RhoA/ROCK pathway

Chengtian Lv, Yu-Wen Huang, Ruirong Yan, Yuanmei Gao

BMC Pulmonary Medicine · 2023 · 13 citations · 26 references

DOIFull text

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Abstract

In conclusion, the results suggest that the promigratory function of VEGF activates the RhoA/ROCK pathway, induces F-actin reorganization, improves the migration of ASMCs, and provides a better rationale for targeting the RhoA/ROCK pathway for therapeutic approaches in airway remodeling.

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