Fully Printed Dual-Gate Organic Electrochemical Synaptic Transistor With Neurotransmitter-Mediated Plasticity

Abstract

Implementation of biohybrid artificial synapses capable of neurotransmitter regulation is a key to establishing active interactions with biological tissues. In this letter, we report a fully printed biohybrid artificial synapse based on an organic electrochemical transistor (OECT) device with low driving voltages (< 1 V), good reproducibility and stability. The OECT shows not only short-term plasticity dominated by sodium ionic dynamic, but also dopamine-mediated long-term plasticity. Furthermore, a dual-gate OECT-based artificial synapse was obtained using the printing technique, aiming to mimic multiple presynaptic dopamine stimulations. Logic AND operation and continuous dopamine-mediated plasticity were subsequently demonstrated in the dual-gate OECT synapse. These results show that the fully printed OECT device can sever as a promising candidate for artificial synapses with dopamine-mediated plasticity for bio-electronic interfaces.