Concepedia

PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice

Wang Ka Lee, Thomas Ka‐Yam Lam, Hiu Ching Tang, Tsz Chun Ho, Hin Ting Wan, Chris K.C. Wong

Frontiers in Endocrinology · 2023 · 19 citations · 39 references

DOIFull text

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Abstract

This study revealed potential links between PFOS-elicited changes in hepatic metabolism and their impacts on testicular biology. This study provides insights into alternative targets elicited by PFOS that can be used to develop diagnostic and therapeutic strategies for improving testicular dysfunction.

References

39

Exposure to per- and Polyfluoroalkyl Substances and Markers of Liver Injury: A Systematic Review and Meta-Analysis

Environmental Health Perspectives · 2022 · 353 citations · Full text

Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease

Partho Sen, S. U. Qadri, Panu K. Luukkonen et al. · Journal of Hepatology · 2021 · 260 citations · Full text

Perfluorooctanoic Acid Induced Developmental Toxicity in the Mouse is Dependent on Expression of Peroxisome Proliferator Activated Receptor-alpha

Barbara D. Abbott, Cynthia J. Wolf, Judy Schmid et al. · Toxicological Sciences · 2007 · 256 citations · Full text

Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes

James A. Bjork, John L. Butenhoff, Kendall B. Wallace · Toxicology · 2011 · 253 citations

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Albumin is the major carrier protein for PFOS, PFOA, PFHxS, PFNA and PFDA in human plasma

Martin Forsthuber, Andreas Kaiser, Sebastian Granitzer et al. · Environment International · 2020 · 249 citations · Full text

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