Concepedia

Reprogramming Exosomes to Escape from Immune Surveillance for Mitochondrial Protection in Hepatic Ischemia-Reperfusion Injury

Shanshan Liu, Xinyu Xiao, Zhang La, Jianwei Wang, Wei Zhao, Haichuan Liu, Rui Liao, Zhi Li, Mengxia Xu, Jiao Guo,

Theranostics · 2023 · 25 citations · 29 references

DOIFull text

Open access

Concepts

Abstract

The reprogramming of exosomes with CD47 and HuR for targeted delivery of CsA and miR inhibitors represents a promising therapeutic strategy for addressing HIRI. This approach shows potential for safe and effective clinical applications in the treatment of HIRI.

References

29

Predicting effective microRNA target sites in mammalian mRNAs

Vikram Agarwal, George W. Bell, Jin‐Wu Nam et al. · eLife · 2015 · 7.7K citations · Full text

, , +16

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Stephen B. Willingham, Jens-Peter Volkmer, Andrew J. Gentles et al. · Proceedings of the National Academy of Sciences · 2012 · 1.7K citations · Full text

, , +17

Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic acute kidney injury by disrupting TFAM-mediated mtDNA maintenance

Meng Zhao, Yizhuo Wang, Ling Li et al. · Theranostics · 2020 · 789 citations · Full text

, , +17

Mitochondrial Damage and Activation of the STING Pathway Lead to Renal Inflammation and Fibrosis

Ki Wung Chung, Poonam Dhillon, Shizheng Huang et al. · Cell Metabolism · 2019 · 636 citations · Full text

, , +16

Hypothermic Machine Perfusion in Liver Transplantation — A Randomized Trial

Rianne van Rijn, Ivo J. Schurink, Y. de Vries et al. · New England Journal of Medicine · 2021 · 620 citations · Full text

, , +15