Cystic fibrosis airway inflammation enables elexacaftor/tezacaftor/ivacaftor-mediated rescue of N1303K<i>CFTR</i>mutation

Abstract

<b>Rescue of N1303K <i>CFTR</i> by highly effective modulator therapy (HEMT) is enabled by CF airway inflammation. These findings suggest that evaluation of HEMT for rare <i>CFTR</i> mutations must be performed under inflammatory conditions relevant to CF airways.</b> https://bit.ly/3tTcoJE.