Biological and Computational Investigation of Transition metal(II) Complexes of 2-phenoxyaniline-based Ligands

Abstract

<b>Aim:</b> In the 21st century, we are witness of continuous onslaughts of various pathogen deformities which are a major cause of morbidity and mortality worldwide. Therefore, to investigate the grave for these deformities, antioxidant, anti-inflammatory and antimicrobial biological activities were carried out against newly synthesized Schiff base ligands and their transition metal complexes, which are based on newly synthesized 2-phenoxyaniline and salicylaldehyde derivatives. <b>Materials & methods:</b> The synthesized compounds were characterized by various physiochemical studies, demonstrating the octahedral stereochemistry of the complexes. <b>Results:</b> The biological assessments revealed that complex <b>6</b> (3.01 ± 0.01 μM) was found to be highly active for oxidant ailments whereas complex <b>14</b> (7.14 ± 0.05 μM, 0.0041-0.0082 μmol/ml) was observed as highly potent for inflammation and microbial diseases. <b>Conclusion:</b> Overall, the biological and computational studies demonstrate that the nickel(II) complex <b>14</b> can act as an excellent candidate for pathogen deformities.