FDA Modernization Act 2.0: transitioning beyond animal models with human cells, organoids, and AI/ML-based approaches

Clinical development success rates for investigational drugs

Michael Hay, David W. Thomas, John L. Craighead et al. · Nature Biotechnology · 2014 · 2.4K citations

Preclinical Drug Evaluation, Pharmacology, Clinical Trials +6

Cytokine Storm in a Phase 1 Trial of the Anti-CD28 Monoclonal Antibody TGN1412

Ganesh Suntharalingam, Meghan Perry, Stephen Ward et al. · New England Journal of Medicine · 2006 · 2.1K citations

Immunology, Immunologic Mechanism, Cd4 T Cell Responses +20

Personalized medicine: Time for one-person trials

Nicholas J. Schork · Nature · 2015 · 1.2K citations · Full text

Clinical Trials, Personalized Treatment, One-person Trials +4

The Economics of Reproducibility in Preclinical Research

Leonard P. Freedman, Iain Cockburn, Timothy Simcoe · PLoS Biology · 2015 · 1K citations · Full text

Reproducibility Studies, Economics, Translational Medicine +15

Genealogies of mouse inbred strains

J. Beck, Sarah E. Lloyd, Majid Hafezparast et al. · Nature Genetics · 2000 · 830 citations

Knockout Mouse, Quantitative Genetics, Molecular Ecology +7