A dual organelle-targeting photosensitizer based on curcumin for enhanced photodynamic therapy

Abstract

A curcumin-based photosensitizer, CN, can specifically target lipid droplets (LDs) and the endoplasmic reticulum (ER) simultaneously, which can enhance PDT effect of CN due to apoptosis by destroying the ER and ferroptosis by oxidizing PUFAs in LDs.