The macrophage STING-YAP axis controls hepatic steatosis by promoting the autophagic degradation of lipid droplets

Abstract

The macrophage STING-YAP axis controls hepatic steatosis by reprogramming lipid metabolism in a transmembrane protein 205/mitofusin 2/protein disulfide isomerase-dependent pathway. These findings highlight the regulatory mechanism of the macrophage STING-driven YAP activity on lipid control.