Circular <scp>RNA PTP4A2</scp> regulates microglial polarization through <scp>STAT3</scp> to promote neuroinflammation in ischemic stroke

Abstract

These results revealed regulatory mechanisms of circPTP4A2 that stimulated neuroinflammation by driving STAT3-dependent microglial polarization in ischemic brain injury. CircPTP4A2 knockdown reduced cerebral ischemic injury and promoted microglial M2 polarization, which could be a novel therapeutic target for ischemic stroke.