The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

Life Sciences, Bioinformatics, Biostatistics +15

Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction Networks

Paul Shannon, Andrew Markiel, Owen Ozier et al. · Genome Research · 2003 · 54.3K citations · Full text

Life Sciences, Bioinformatics, Molecular Biology +17

The SILVA ribosomal RNA gene database project: improved data processing and web-based tools

Christian Quast, Elmar Pruesse, Pelin Yilmaz et al. · Nucleic Acids Research · 2012 · 34K citations · Full text

Life Sciences, Bioinformatics, Microbiology +17

fastp: an ultra-fast all-in-one FASTQ preprocessor

Shifu Chen, Yanqing Zhou, Yaru Chen et al. · Bioinformatics · 2018 · 29.7K citations · Full text

Computing, Computer Engineering, Computer Science +8

HISAT: a fast spliced aligner with low memory requirements

Daehwan Kim, Ben Langmead, Steven L. Salzberg · Nature Methods · 2015 · 26.1K citations · Full text

Engineering, Computer Engineering, Computer Science +3