Concepedia

Red-light modulated <i>ortho</i> -chloro azobenzene photoswitch for peptide stapling <i>via</i> aromatic substitution

Mia Kapun, F. Javier Pérez-Areales, Nicola Ashman, Pamela J. E. Rowling, Tim Schober, Elaine Fowler, Laura S. Itzhaki, David R. Spring

RSC Chemical Biology · 2023 · 14 citations · 25 references

DOIFull text

Open access

Concepts

Abstract

Development and proof-of-concept for a photoswitchable peptide staple with the ability to trigger a major change in binding affinity upon visible light irradiation.

References

25

Photopharmacology: Beyond Proof of Principle

Willem A. Velema, Wiktor Szymański, Ben L. Feringa · Journal of the American Chemical Society · 2014 · 1.2K citations · Full text

, , +13

Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods

Caerwyn Ash, Michael J. Dubec, Kelvin Donne et al. · Lasers in Medical Science · 2017 · 1K citations · Full text

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<i>o</i>-Fluoroazobenzenes as Readily Synthesized Photoswitches Offering Nearly Quantitative Two-Way Isomerization with Visible Light

David Bléger, Jutta Schwarz, Albert M. Brouwer et al. · Journal of the American Chemical Society · 2012 · 872 citations

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Photoswitching Azo Compounds in Vivo with Red Light

Subhas Samanta, Andrew A. Beharry, Oleg Sadovski et al. · Journal of the American Chemical Society · 2013 · 537 citations

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A Perfluoroaryl-Cysteine S <sub>N</sub> Ar Chemistry Approach to Unprotected Peptide Stapling

Alexander M. Spokoyny, Yekui Zou, Jingjing Ling et al. · Journal of the American Chemical Society · 2013 · 465 citations

, , +17