Ginsenoside Rg1 ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in mice exposed to chronic stress

Sucrose preference test for measurement of stress-induced anhedonia in mice

Mengying Liu, Chunyu Yin, Li‐Juan Zhu et al. · Nature Protocols · 2018 · 1K citations

Veterinary Medicine, Behavioral Sciences, Neuroscience +6

NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder

Elísabet Alcocer‐Gómez, N. Casas Barquero, Jéssica Núñez‐Vasco et al. · Brain Behavior and Immunity · 2013 · 445 citations · Full text

Life Sciences, Immunology, Psychiatry +13

Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats

Ying Pan, Xu-Yang Chen, Qingyu Zhang et al. · Brain Behavior and Immunity · 2014 · 401 citations

Life Sciences, Immunology, Neuroscience +16

IL4-driven microglia modulate stress resilience through BDNF-dependent neurogenesis

Jinqiang Zhang, Peijing Rong, Lijuan Zhang et al. · Science Advances · 2021 · 273 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Antidepressant‐like effects of ginsenoside Rg1 are due to activation of the BDNF signalling pathway and neurogenesis in the hippocampus

Bo Jiang, Zhe Xiong, Jun Yang et al. · British Journal of Pharmacology · 2012 · 237 citations

Medicine, Neurobiology, Neuroscience +15