Theranostics · 2023 · 66 citations · 55 references
Life SciencesImmunologyMolecular BiologyInflammationMechanobiologyTranscriptional RegulationFibrosisHepatic FibrosisHepatic PathophysiologyInflammatory SignalingMacrophage BiologyMechanical Signaling Between CellsCathepsin ActivityEpithelial-mesenchymal Transition MarkersLiver Fibrosis ProgressionMacrophage Inflammatory ResponsesMacrophage MechanobiologyMacrophage Transcriptional RegulationMacrophage-mediated FibrosisTranscriptomic Profiling Of Fibrosis
Macrophage Piezo1 deficiency limits the progression of liver fibrosis by inhibited inflammatory response and decreased secretion of CTSS. These findings suggest that targeting Piezo1 channel may be a potential strategy for treating hepatic fibrosis.
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Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels
Bertrand Coste, Jayanti Mathur, Manuela Schmidt et al. · Science · 2010 · 3.2K citations · Full text