1e:T4d1,Many different techniques have been proposed for performing uncertainty and sensitivity analyses on computer models for complex processes. The objective of the present study is to investigate the applicability of three widely used techniques to three computer models having large uncertainties and varying degrees of complexity in order to highlight some of the problem areas that must be addressed in actual applications. The following approaches to uncertainty and sensitivity analysis are considered: (1) response surface methodology based on input determined from a fractional factorial design; (2) Latin hypercube sampling with and without regression analysis; and (3) differential analysis. These techniques are investigated with respect to (1) ease of implementation, (2) flexibility, (3) estimation of the cumulative distribution function of the output, and (4) adaptability to different methods of sensitivity analysis. With respect to these criteria, the technique using Latin hypercube sampling and regression analysis had the best overall performance. The models used in the investigation are well documented, thus making it possible for researchers to make comparisons of other techniques with the results in this study.1f:T483,ALTHOUGH CURABLE, TB frequently leaves the individual with chronic physical and psycho-social impairment, but these consequences have been largely neglected. The 1^st International Post-Tuberculosis Symposium (Stellenbosch, South Africa) was held to discuss priorities and gaps in addressing this issue. A barrier to progress has been the varied terminology and nomenclature, so the Delphi process was used to achieve consensus on definitions. Lack of sufficient evidence hampered definitive recommendations in most domains, including prevention and treatment of post-TB lung disease (PTLD), but the discussions clarified the research needed. A consensus was reached on a toolkit for future PTLD measurement and on PTLD patterns to be considered. The importance of extra-pulmonary consequences and progressive impairment throughout the life-course was identified, including TB recurrence and increased mortality. Patient advocates emphasised the need to address the psychological and social impacts post TB and called for clinical guidance. More generally, there is an urgent need for increased awareness and research into post-TB complications.20:T540,BACKGROUND: Increasing evidence suggests that post-TB lung disease (PTLD) causes significant morbidity and mortality. The aim of these clinical standards is to provide guidance on the assessment and management of PTLD and the implementation of pulmonary rehabilitation (PR).METHODS: A panel of global experts in the field of TB care and PR was identified; 62 participated in a Delphi process. A 5-point Likert scale was used to score the initial ideas for standards and after several rounds of revision the document was approved (with 100% agreement).RESULTS: Five clinical standards were defined: Standard 1, to assess patients at the end of TB treatment for PTLD (with adaptation for children and specific settings/situations); Standard 2, to identify patients with PTLD for PR; Standard 3, tailoring the PR programme to patient needs and the local setting; Standard 4, to evaluate the effectiveness of PR; and Standard 5, to conduct education and counselling. Standard 6 addresses public health aspects of PTLD and outcomes due to PR.CONCLUSION: This is the first consensus-based set of Clinical Standards for PTLD. Our aim is to improve patient care and quality of life by guiding clinicians, programme managers and public health officers in planning and implementing adequate measures to assess and manage PTLD.

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