Application of Lipase B from <i>Candida antarctica</i> in the Pharmaceutical Industry

Abstract

The use of biocatalysts in pharmaceutical production is an important approach for the pharmaceutical industry to achieve green manufacturing. Compared to other lipases, Candida antarctica lipase B (CALB) possesses numerous excellent characteristics due to its unique structure. It exhibits relatively strong catalytic activity toward both water-insoluble and water-soluble substances. It shows high selectivity in hydrolysis and organic synthesis reactions. These properties are crucial for drug synthesis. However, current research shows that the use of CALB as a catalyst still faces challenges such as high cost, poor stability, and difficulty in large-scale production. Therefore, this paper mainly explores the advantages of CALB in the pharmaceutical industry and the challenges that still need to be overcome. It introduces the application progress of CALB in the pharmaceutical industry and finally provides a prospect for future research directions, hoping to provide appropriate references for related research.