CD8⁺ T cell infiltration and proliferation in the brainstem during experimental cerebral malaria

Abstract

These findings reveal a novel interaction between brain-infiltrated CD8⁺ T cells and parenchyma cells in the ECM brainstem, suggesting that the PD-1/PD-L1 signal pathway is a promising adjunctive therapeutic strategy for ECM targeting over-activated CD8⁺ T cells.