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Publication | Open Access

Loss of 12-Lipoxygenase Improves the Post-Transfusion Function of Stored Platelets

DOIFull Paper Access

12

Citations

36

References

2023

Year

Hannah J. Larsen, Daire Byrne, Tahsin Özpolat, Aastha Chauhan, S. Lawrence Bailey, Nicole Rhoads, Franklin Reed, Massiel Chavez Stolla, Reheman Adili, Michael Holinstat,
Arteriosclerosis Thrombosis and Vascular Biology

Abstract

Deleting 12-LOX improves the post-transfusion function of stored murine platelets by increasing thromboxane generation through COX-1-dependent arachidonic acid metabolism. Future studies should determine the feasibility and safety of 12-LOX-inhibited platelets transfused to humans.

References

YearCitations

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