Expression profiling identifies key genes and biological functions associated with eosinophilic esophagitis in human patients

Abstract

Our findings suggest that there is epithelial dysregulation demonstrated by DEGs that may contribute to impaired barrier integrity and loss of epidermal cell differentiation in EoE patients. These findings present two new gene families, <i>SPRR</i> and <i>MUC</i>, that are differentially expressed in both adult and pediatric EoE patients, which presents an opportunity for a future therapeutic target that would be useful in a large demographic of patients.