SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter - Concepedia

Concepedia

Publication | Open Access

SIRT6 deficiency in endothelial cells exacerbates oxidative stress by enhancing HIF1α accumulation and H3K9 acetylation at the Ero1α promoter

DOI Full Paper Access

29

Citations

30

References

2023

Year

Zhenyang Guo, Xueting Yu, Shuang Zhao, Xin Zhong, Dong Huang, Runyang Feng, Peng Li, Zheyan Fang, Yiqing Hu, Zhentao Zhang,

Clinical and Translational Medicine

Abstract

Our results revealed an epigenetic mechanism associated with SIRT6 and Ero1α expression and highlighted the therapeutic potential of targeting the SIRT6-HIF1α/p300-Ero1α axis.

References

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