Cu(II)‐Catalyzed [3+2]‐Annulation of 2‐Pyridinyl‐substituted <i>p</i>‐Quinone Methides with Enaminones: Access to Functionalized Indolizine Derivatives

Abstract

Abstract This article describes an effective and atom‐economical protocol to access a wide range of synthetically important functionalized indolizine derivatives. This transformation basically takes place through a Cu(II) catalyzed formal [3+2] annulation of 2‐pyridinyl substituted p ‐quinone methides with enaminones. This method displayed a good functional group tolerance and, was found to be effective for most of the enaminones and p ‐QMs, and the corresponding indolizines were obtained in moderate to good yields.