Concepedia

Secretome of senescent hepatic stellate cells favors malignant transformation from nonalcoholic steatohepatitis-fibrotic progression to hepatocellular carcinoma

Yuan Zhou, Li Zhang, Yue Ma, Li Xie, Yang Yong-yu, Jin Cheng, Hui Chen, Ying Zhou, Guangqi Song, Jia Ding,

Theranostics · 2023 · 28 citations · 31 references

DOIFull text

Open access

Concepts

Abstract

Senescent HSCs secreted a characterized protein profile favoring malignant transformation of steatotic or dysplastic hepatocytes through activating morphogenic hedgehog or oncogenic Wnt signaling pathways in the progression from NASH to malignancy.

References

31

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Shin Yoshimoto, Tze Mun Loo, Koji Atarashi et al. · Nature · 2013 · 2.2K citations

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Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis

Liang‐Guo Xu · Gut · 2004 · 1K citations · Full text

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Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

Xiaoni Kong, Dechun Feng, Hua Wang et al. · Hepatology · 2012 · 442 citations · Full text

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Upregulation of proinflammatory and proangiogenic cytokines by leptin in human hepatic stellate cells†

Sara Aleffi, Ilaria Petrai, Cristiana Bertolani et al. · Hepatology · 2005 · 336 citations · Full text

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Inhibition of T–Cell Responses by Hepatic Stellate Cells Via B7–H1-Mediated T–Cell Apoptosis in Mice

Cheng‐Hsu Chen, Xiaoyan Liang, Lianfu Wang et al. · Hepatology · 2004 · 299 citations

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