Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.1K citations · Full text

Inflammation, Nalp3 Inflammasome, Urology +7

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Haiping Wang, Xiaoyun Li, Tung Chao et al. · Nature Immunology · 2017 · 1.1K citations · Full text

Epigenetic Reprogramming, Metabolic Regulation, Metabolism +2

Identification of Serum Metabolites Associated With Risk of Type 2 Diabetes Using a Targeted Metabolomic Approach

Anna Floegel, Norbert Stefan, Zhonghao Yu et al. · Diabetes · 2012 · 997 citations · Full text

T2d Prediction, Metabolic Syndrome, Metabolic Disorder +15

A Map of Protein-Metabolite Interactions Reveals Principles of Chemical Communication

Ilaria Piazza, Karl Kochanowski, Valentina Cappelletti et al. · Cell · 2018 · 542 citations · Full text

Metabolic Network, Chemical Communication, Biochemistry +7

The Inflammasome Mediates UVB-Induced Activation and Secretion of Interleukin-1β by Keratinocytes

Laurence Feldmeyer, Martin Keller, Gisela Niklaus et al. · Current Biology · 2007 · 519 citations · Full text

Inflammation, Cytokine, Cutaneous Biology +7