Concepedia

Association between gut microbiota and gastrointestinal cancer: a two-sample bi-directional Mendelian randomization study

Qing Su, Jin Chen, Zhiyuan Bo, Yi Yang, Jingxian Wang, Juejin Wang, Junxi Zhou, Yaqing Chen, Hao Zeng, Gang Chen,

Frontiers in Microbiology · 2023 · 33 citations · 35 references

DOIFull text

Open access

Abstract

Our study implicates the potential causal effects of specific microbial taxa on GI cancer, potentially providing new insights into the prevention and treatment of GI cancer through specific gut bacteria.

References

35

Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel et al. · CA A Cancer Journal for Clinicians · 2021 · 109.5K citations · Full text

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

Jack Bowden, George Davey Smith, Stephen Burgess · International Journal of Epidemiology · 2015 · 10.2K citations · Full text

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

Jack Bowden, George Davey Smith, Philip Haycock et al. · Genetic Epidemiology · 2016 · 9.2K citations · Full text

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

Marie Verbanck, Chia‐Yen Chen, Benjamin M. Neale et al. · Nature Genetics · 2018 · 8.8K citations · Full text

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Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians

Neil M Davies, Michael V. Holmes, George Davey Smith · BMJ · 2018 · 4.5K citations · Full text