Systems pharmacology-based mechanism exploration of Acanthopanax senticosusin for Alzheimer's disease using UPLC-Q-TOF-MS, network analysis, and experimental validation

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Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease

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TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

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Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease

Jiansong Fang, Pengyue Zhang, Yadi Zhou et al. · Nature Aging · 2021 · 200 citations · Full text

Life Sciences, Pharmacology, Pharmacotherapy +14

HIT 2.0: an enhanced platform for Herbal Ingredients' Targets

Deyu Yan, Genhui Zheng, Caicui Wang et al. · Nucleic Acids Research · 2021 · 186 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17