Theranostics · 2023 · 132 citations · 32 references
Life SciencesCell BiologyImmunologyCell SignalingInflammationInnate ImmunityGlycolysis RegulationHepatic NecrosisHepatic PathophysiologyImmune-mediated InjuryInflammatory SignalingMacrophage BiologyDamage-associated Molecular Pattern SignalingDamage-associated Molecular PatternsHepatic Inflammatory InjuryHepatocellular Injury MechanismsHigh-mobility Group Box 1 ProteinInflammatory CascadeInflammatory Liver InjuryLiver Injury Response
Taken together, these findings suggest that hepatocyte HSPA12A is a novel regulator that protects livers from LI/R injury by suppressing glycolysis-mediated HMGB1 lactylation and secretion from hepatocytes to inhibit macrophage chemotaxis and inflammatory activation. Therefore, targeting hepatocyte HSPA12A may have therapeutic potential in the management of LI/R injury in patients.
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Metabolic regulation of gene expression by histone lactylation
Di Zhang, Zhanyun Tang, He Huang et al. · Nature · 2019 · 3.9K citations · Full text